Perfluorinated compounds and their derivatives are man-made chemicals that have been used in a wide range of products, including garments and textiles, fabric protection, furniture, and some types of fire-fighting foam.
There are three principal contaminants that may be found in contaminated food: PFOS; PFOA and PFHxS.
The scientific literature on the effects of these chemicals on people is inconclusive. However testing on animals has shown some effects at low doses.
FSANZ work on perfluorinated compounds
The Australian Government Department of Health commissioned FSANZ to:
provide advice on appropriate HBGVs for PFOS, PFOA and PFHxS
conduct a preliminary dietary exposure assessment
make an assessment as to whether a food regulatory measure should be further considered as the most appropriate risk management response.
FSANZ completed its review and provided advice on appropriate HBGVs to the department on 31 December 2016 and recommended tolerable daily intakes (TDIs) of 20 ng/kg bw/day for PFOS and 160 ng/kg bw/day for PFOA. There was insufficient information to establish a TDI for PFHxS; however, the TDI for PFOS is likely to be conservative and protective of public health.
On 28 February 2017, a
consolidated report was submitted to Health that included the report on HBGVs, the dietary exposure report and a risk management report.
FSANZ supports current at-site risk management measures by other Commonwealth, state and territory jurisdictions to manage and reduce potential dietary exposure from these chemicals, rather than setting maximum levels (MLs) in the Food Standards Code.
Whilst there is insufficient data to recommend a regulatory approach and set maximum limits in the Code, FSANZ proposed trigger points for investigation for PFOS + PFHxS combined and PFOA.
These trigger points could be employed by state and territory food jurisdictions when analysing PFAS in foods to identify when further investigation of a food may be required.
For example, when levels of PFAS in analysed foods exceed specific values (trigger points) further investigations or risk management action may be required but this would depend on the relevant jurisdiction and the issues at the particular individual sites.
24th Australian Total Diet Study Phase 2, which analysed perfluorinated compounds in a range of foods in the Australian diet, there were no detections for PFOA and only two detections for PFOS out of 50 foods tested. The concentrations of PFOS were at very low levels (1 part per billion) and similar to those reported internationally for the same foods. Foods were sampled from a range of different retail outlets representing the buying habits of most of the community, including supermarkets, corner stores, delicatessens, markets and takeaway shops.
Following a request from the Food Regulation Standing Committee (FRSC), FSANZ is planning to undertake monitoring of
per- and poly-fluoroalkyl substances (PFAS) in the general food supply as part of the 27th Australian Total Diet Study (ATDS) in 2019.
Previous work on perfluorinated compounds
In 2015, the NSW Food Authority asked FSANZ to provide advice on the Tolerable Daily Intake (TDI) for PFOS established by the European Food Safety Authority (EFSA) in 2008, and on safe maximum levels of PFOS in seafood.
The request was made in relation to areas of localised contamination in NSW.
Based on a comparison of potential estimated dietary exposure to PFOS from consuming oysters sourced from the area of interest in NSW with the EFSA TDI, FSANZ’s preliminary conclusion was that there was low health risk concern for the general population.
For people who may consume large amounts of other seafood from the areas of interest, FSANZ found there is a potential to exceed the EFSA health based guidance value for PFOS for some species of fish or crustacea. However, this is not likely to be the case for the general population. Further research is required on levels of PFOS, PFOA and PFHxS in seafood and other commodities in the food supply.
Read the NSW EPA report.
Health-based guidance values (HBGVs) have also been established for PFOS and PFOA by a number of international agencies including the European Food Safety Authority (EFSA) and the United States Environmental Protection Agency (US EPA). The HBGVs derived by these international agencies range widely, from 20 – 300 ng/kg bw/day for PFOS and 20 – 1,500 ng/kg bw/day for PFOA.
The United States Agency for Toxic Substances and Disease Registry (ATSDR) has published draft minimal risk levels (MRLs) for PFOS and PFOA and new levels for two other perfluoralkyl compounds. The MRLs are a tool for risk assessors to look at a particular site where exposures to a chemical may have occurred. FSANZ will consider the ATSDR report findings when they are published.
On 13 December 2018 EFSA released an
updated scientific opinion on the presence of PFOS and PFOA in food, which established a tolerable weekly intake (TWI) of 13 ng/kg bw for PFOS and 6 ng/kg bw for PFOA.
When converted to tolerable daily intakes these are lower than the FSANZ 2017 recommended values of 20 ng/kg bw/day for PFOS and 160 ng/kg bw/day for PFOA. These levels are the amount a person can consume, every day, for their entire life safely.
The EFSA conclusions and the tolerable weekly intakes are considered provisional on the basis of uncertainties in the report and disagreement with other prominent European scientific agencies.
European agencies have questioned the scientific basis for the tolerable weekly intakes including the robustness of the human data for deriving a health-based guidance value, the overall relevance of the selected endpoints and modelling techniques used by EFSA.
More information is provided in the meeting minutes published by EFSA.
Minutes of the expert meeting (pdf 602kb)
EFSA is reviewing its scientific opinion together with a consideration of the safety of other PFAS chemicals in 2019. Until that time both the conclusions and tolerable weekly intakes are considered provisional and may change.
FSANZ will review the EFSA report to see whether it contains any new information that would warrant a need to reconsider the tolerable daily intakes it published in 2017.